Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …

While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a
substantial morbidity and mortality. Currently there is no specific treatment for the disease …

COVID-19 has caused over 1 million deaths globally, yet the cellular mechanisms
underlying severe disease remain poorly understood. By analyzing several thousand …

Background & Aims Mutations in the human serine protease 1 gene (PRSS1), which
encodes cationic trypsinogen, can accelerate its autoactivation and cause hereditary or …

Acute pancreatitis (AP) is a potential gastrointestinal problem most commonly associated
with pancreatic inflammation and acinar cells injury. Nimbolide (NB), isolated from the tree …

Bisphenol A (BPA) is an endocrine disruptor widely existing in plastics and resins, which can
accumulate in animals and human bodies, posing a potential threat to the physiological and …

Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality.
Clinical studies can provide some data concerning the etiology, pathophysiology, and …