Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

This article is part of the Top 10 Unanswered Questions in MPMI invited review series.
Plants recognize the presence or invasion of microbes through cell surface-localized pattern …

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Lung cancer is the leading cause of cancer death worldwide. In the past decade EGFR, ALK
and ROS1 TKIs lead to an unprecedented survival improvement of oncogene-addicted …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal
dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here …

Valid experimental evidence has recently shown that progression of malignant tumors does
not depend exclusively on cell-autonomous properties of the cancer cells, but is also deeply …

The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …

Several recent papers have now provided compelling experimental evidence that the
progression of tumours towards a malignant phenotype does not depend exclusively on the …

It is widely acknowledged that integrins, the major receptors for the extracellular matrix
(ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors …