CD4 T helper cell subsets and related human immunological disorders
The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
The mycobiota: interactions between commensal fungi and the host immune system
DM Underhill, ID Iliev - Nature Reviews Immunology, 2014 - nature.com
The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …
protects us and that are important for the normal development of the immune system and for …
B-cell biology and development
K Pieper, B Grimbacher, H Eibel - Journal of Allergy and Clinical …, 2013 - Elsevier
B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …
process. Extensive studies with many different mouse mutants provided fundamental …
The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies
DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …
Hematopoietic stem cell transplantation in primary immunodeficiency diseases: current status and future perspectives
Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …
in genes involved in immune host defense and immunoregulation. These conditions are …
IRF and STAT transcription factors-from basic biology to roles in infection, protective immunity, and primary immunodeficiencies
TH Mogensen - Frontiers in immunology, 2019 - frontiersin.org
The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling
Motivation: Exome sequencing has proven to be an effective tool to discover the genetic
basis of Mendelian disorders. It is well established that copy number variants (CNVs) …
basis of Mendelian disorders. It is well established that copy number variants (CNVs) …
DOCK8 deficiency: clinical and immunological phenotype and treatment options-a review of 136 patients
SE Aydin, SS Kilic, C Aytekin, A Kumar… - Journal of clinical …, 2015 - Springer
Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …
Practice parameter for the diagnosis and management of primary immunodeficiency
FA Bonilla, DA Khan, ZK Ballas, J Chinen… - Journal of Allergy and …, 2015 - Elsevier
The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …