Studying non-covalent drug–DNA interactions
Drug–DNA interactions have been extensively studied in the recent past. Various
techniques have been employed to decipher these interactions. DNA is a major target for a …
techniques have been employed to decipher these interactions. DNA is a major target for a …
Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling
A Rescifina, C Zagni, MG Varrica, V Pistarà… - European journal of …, 2014 - Elsevier
The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …
Drug–DNA intercalation: From discovery to the molecular mechanism
A Mukherjee, WD Sasikala - Advances in protein chemistry and structural …, 2013 - Elsevier
The ability of small molecules to perturb the natural structure and dynamics of nucleic acids
is intriguing and has potential applications in cancer therapeutics. Intercalation is a special …
is intriguing and has potential applications in cancer therapeutics. Intercalation is a special …
Comparative study regarding the properties of methylene blue and proflavine and their optimal concentrations for in vitro and in vivo applications
Methylene blue and proflavine are fluorescent dyes used to stain nucleic acid from the
molecular level to the tissue level. Already clinically used for sentinel node mapping …
molecular level to the tissue level. Already clinically used for sentinel node mapping …
Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and delivery
This work is focused on the development of a plant virus-based carrier system for cargo
delivery, specifically 30 nm-sized cowpea mosaic virus (CPMV). Whereas previous reports …
delivery, specifically 30 nm-sized cowpea mosaic virus (CPMV). Whereas previous reports …
What can electrochemical methods offer in determining DNA–drug interactions?
The interactions of compounds with DNA have been studied since the recognition of the role
of nucleic acid in organisms. The design of molecules which specifically interact with DNA …
of nucleic acid in organisms. The design of molecules which specifically interact with DNA …
Spectroscopic and molecular docking evidence of aspirin and diflunisal binding to DNA: a comparative study
Aspirin and diflunisal belong to the salicylate class of non-steroidal anti-inflammatory drugs
with diverse pharmacological and biological activities. Deciphering the interaction of drugs …
with diverse pharmacological and biological activities. Deciphering the interaction of drugs …
Unique features of metformin: a combined experimental, theoretical, and simulation study of its structure, dynamics, and interaction energetics with DNA grooves
There are certain small molecules that exhibit extraordinarily diverse biological activities.
Metformin is one of them. It is widely used as an antidiabetic drug for type-two diabetes …
Metformin is one of them. It is widely used as an antidiabetic drug for type-two diabetes …
Intercalation and de-intercalation pathway of proflavine through the minor and major grooves of DNA: roles of water and entropy
WD Sasikala, A Mukherjee - Physical Chemistry Chemical Physics, 2013 - pubs.rsc.org
DNA intercalation is a clinically relevant biophysical process due to its potential to inhibit the
growth and survival of tumor cells and microbes through the arrest of the transcription and …
growth and survival of tumor cells and microbes through the arrest of the transcription and …
Synthesis, characterization, biological evaluation and DNA interaction studies of 4-aminophenol derivatives: theoretical and experimental approach
In the present study, five 4-aminophenol derivatives (4-chloro-2-(((4-hydroxyphenyl) imino)
methyl) phenol (S-1), 4-((4-(dimethylamino) benzylidene) amino) phenol (S-2), 4-((3 …
methyl) phenol (S-1), 4-((4-(dimethylamino) benzylidene) amino) phenol (S-2), 4-((3 …