Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

Wireless, battery-free implants for electrochemical catecholamine sensing and optogenetic stimulation

T Stuart, WJ Jeang, RA Slivicki, BJ Brown, A Burton… - ACS …, 2022 - ACS Publications
Neurotransmitters and neuromodulators mediate communication between neurons and
other cell types; knowledge of release dynamics is critical to understanding their …

Brain mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspective

H Ackermann, SR Hage, W Ziegler - Behavioral and Brain Sciences, 2014 - cambridge.org
Any account of “what is special about the human brain”(Passingham 2008) must specify the
neural basis of our unique ability to produce speech and delineate how these remarkable …

A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies

PJ Grahn, GW Mallory, OU Khurram, BM Berry… - Frontiers in …, 2014 - frontiersin.org
Current strategies for optimizing deep brain stimulation (DBS) therapy involve multiple
postoperative visits. During each visit, stimulation parameters are adjusted until desired …

Deep brain stimulation of the human reward system for major depression—rationale, outcomes and outlook

TE Schlaepfer, BH Bewernick, S Kayser… - …, 2014 - nature.com
Deep brain stimulation (DBS) as a putative approach for treatment-resistant depression
(TRD) has now been researched for about a decade. Several uncontrolled studies—all in …

Neuroplasticity in levodopa-induced dyskinesias: an overview on pathophysiology and therapeutic targets

F Bove, B Angeloni, P Sanginario, PM Rossini… - Progress in …, 2024 - Elsevier
Levodopa-induced dyskinesias (LIDs) are a common complication in patients with
Parkinson's disease (PD). A complex cascade of electrophysiological and molecular events …

Toward sophisticated basal ganglia neuromodulation: review on basal ganglia deep brain stimulation

C Da Cunha, SL Boschen, A Gómez-a, EK Ross… - Neuroscience & …, 2015 - Elsevier
This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in
action-selection, cognition, and motivation, and how this knowledge has been used to …

Caudate stimulation enhances learning

SK Bick, SR Patel, HA Katnani, N Peled, A Widge… - Brain, 2019 - academic.oup.com
Neuromodulation is a promising treatment modality for disorders of learning and memory,
offering the possibility of precise alteration of disordered neural circuits. Studies to date have …

[HTML][HTML] Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation

Y Li, SH Lee, C Yu, LM Hsu, TWW Wang, K Do, HJ Kim… - Brain stimulation, 2024 - Elsevier
While deep brain stimulation (DBS) is widely employed for managing motor symptoms in
Parkinson's disease (PD), its exact circuit mechanisms remain controversial. To identify the …