Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

With the recent explosion in high-throughput genotyping technology, the amount and quality
of SNP data have increased exponentially, facilitating the discovery of multiple uncommon …

Background: Development and worldwide availability of safe and effective vaccines against
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to fight severe symptoms of …

Background: Somatic TP53 mutations are frequent in head and neck squamous cell
carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 …

Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis.
Therefore, developing novel effective markers and therapeutic targets for gastrointestinal …

Molecular profiling may enable earlier detection of pancreatic cancer (PC) in high-risk
individuals undergoing surveillance and allow for personalization of treatment. We …

In eukaryotes, transcripts that carry premature termination codons (PTC) leading to truncated
proteins are degraded by the Nonsense Mediated Decay (NMD) machinery. Missense and …

The ideal technology for directly investigating the relationship between genotype and
phenotype would analyze both RNA and DNA genome-wide and with single-cell resolution …

Background Prostate cancer (PCa) is a leading cause of cancer-related deaths in European
men, emphasizing the urgent need for effective risk assessment strategies. The TP53 gene …

Germline, mono-allelic mutations in RUNX1 cause familial platelet disorder (RUNX1-FPD)
that evolves into myeloid malignancy (FPD-MM): MDS or AML. FPD-MM commonly harbors …