This Perspective is the seventh in an annual series that summarizes successful Fragment-to-
Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles …

Immune checkpoints inhibition is a privileged approach to combat cancers and other human
diseases. The TIM-3 (T cell immunoglobulin and mucin-domain containing-3) inhibitory …

T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed in dysfunctional
and exhausted T cells, has been widely acknowledged as a promising immune checkpoint …

Prior research has shown an elevation in autism traits and diagnoses in individuals seen for
gender related consultation and in participants self-identifying as transgender. To …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

T-cell immunoglobulin and mucin domain 3 (TIM-3) is a negative immune checkpoint that
represents a promising target for cancer immunotherapy. Although encouraging results have …

Ferritin, which includes twenty-four light and heavy chains in varying proportions in different
tissues, is primarily responsible for maintaining the body's iron metabolism. Its normal value …

Diffusion probabilistic models have made their way into a number of high-profile
applications since their inception. In particular, there has been a wave of research into using …

Simple Summary The disaccharide lactose is a common excipient in pharmaceutical
products. In addition, the two anomers α-and β-lactose can exert immuno-modulatory effects …

Neglected tropical parasitic diseases (NTD) are prevalent in many countries and cost-
effective treatments remain urgently needed. Novel approaches have been proposed to …