Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …

Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Leptin is an adipocyte-derived hormone involved in a myriad of physiological process,
including the control of energy balance and several neuroendocrine axes. Leptin-deficient …

Abstract Objective Leptin receptor (LepR) deficiency is an autosomal-recessive endocrine
disorder causing early-onset severe obesity, hyperphagia and pituitary hormone …

The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body
weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However …

The studies based on candidate genes and encoded proteins known to cause severe
obesity in rodents, have shown that these genes also contribute to human early-onset …