Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …

The approval of combination therapies with direct-acting antiviral (DAA) regimens has led to
significant progress in the field of hepatitis C virus (HCV) treatment. Although most patients …

Populations of RNA viruses are composed of complex and dynamic mixtures of variant
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-
based treatment regimens, often because of drug resistance-associated substitutions (RAS) …

We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …

Mutant spectra of RNA viruses are important to understand viral pathogenesis and response
to selective pressures. There is a need to characterize the complexity of mutant spectra in …

Background and Purpose There is a need for effective anti‐COVID‐19 treatments, mainly for
individuals at risk of severe disease such as the elderly and the immunosuppressed. Drug …

Owing to the rapid development and wide clinical application of direct acting antiviral (DAA)
drugs in the treatment of hepatitis C virus (HCV) infection, the era of interferon-based …

ABSTRACT A common trait among RNA viruses is their high capability to acquire genetic
variability due to viral and host mechanisms. Next-generation sequencing (NGS) analysis …

The repeated failure to treat patients chronically infected with hepatitis E (HEV) and C (HCV)
viruses, despite the absence of resistance-associated substitutions (RAS), particularly in …