Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

The crosstalk between metabolism and translation

S Biffo, D Ruggero, MM Santoro - Cell Metabolism, 2024 - cell.com
Metabolism and mRNA translation represent critical steps involved in modulating gene
expression and cellular physiology. Being the most energy-consuming process in the cell …

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

K Wang, M Khoramjoo, K Srinivasan, PMK Gordon… - Cell Reports …, 2023 - cell.com
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often
associated with debilitating symptoms and adverse multisystem consequences. We obtain …

Decoding aging clocks: new insights from metabolomics

H Huang, Y Chen, W Xu, L Cao, K Qian, E Bischof… - Cell Metabolism, 2025 - cell.com
Chronological age is a crucial risk factor for diseases and disabilities among older adults.
However, individuals of the same chronological age often exhibit divergent biological aging …

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

D Petrovic, L Slade, Y Paikopoulos, D D'Andrea… - Cell Metabolism, 2025 - cell.com
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible
benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on …

Taurine modulates host cell responses to Helicobacter pylori VacA toxin

MD Westland, AC Schrimpe-Rutledge… - Infection and …, 2024 - journals.asm.org
Colonization of the human stomach with Helicobacter pylori strains producing active forms of
the secreted toxin VacA is associated with an increased risk of peptic ulcer disease and …

An mTOR inhibitor discovery system using drug-sensitized yeast

AK Breen, S Thomas, D Beckett, M Agsalud, G Gingras… - GeroScience, 2025 - Springer
Inhibition of the target of rapamycin (TOR/mTOR) protein kinase by the drug rapamycin
extends lifespan and health span across diverse species. However, rapamycin has potential …

An insight into role of amino acids as antioxidants via NRF2 activation

MC Egbujor, OT Olaniyan, CN Emeruwa, S Saha… - Amino Acids, 2024 - Springer
Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial
role in several pathophysiological conditions. It has already been established that oxidative …

Modeling of Intracellular Taurine Levels in Ovarian Cancer

D Centeno - 2024 - search.proquest.com
Taurine, a non-proteogenic amino acid commonly used as a nutritional supplement,
possesses numerous cytoprotective properties that support human health and cellular …