Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects
Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …
Serine/Threonine kinases family. They are the downstream target of various signaling …
Micro RNA s in myeloid malignancies
JEA Gordon, JJL Wong… - British journal of …, 2013 - Wiley Online Library
Micro RNA s (mi RNA s) are key to the pathogenesis of human malignancies and
increasingly recognized as potential biomarkers and therapeutic targets. Haematological …
increasingly recognized as potential biomarkers and therapeutic targets. Haematological …
The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression
M Abraham, S Klein, B Bulvik, H Wald, ID Weiss… - Leukemia, 2017 - nature.com
CXCR4 is a key player in the retention and survival of human acute myeloid leukemia (AML)
blasts in the bone marrow (BM) microenvironment. We studied the effects of the CXCR4 …
blasts in the bone marrow (BM) microenvironment. We studied the effects of the CXCR4 …
The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by …
K Natarajan, J Bhullar, S Shukla, M Burcu… - Biochemical …, 2013 - Elsevier
Overexpression of the ATP-binding cassette (ABC) drug efflux proteins P-glycoprotein
(ABCB1) and breast cancer resistance protein (ABCG2) on malignant cells is associated …
(ABCB1) and breast cancer resistance protein (ABCG2) on malignant cells is associated …
Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma
K Teshima, M Nara, A Watanabe, M Ito, S Ikeda… - Oncogene, 2014 - nature.com
The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of
tumors, particularly in aggressive tumors and tumors resistant to conventional …
tumors, particularly in aggressive tumors and tumors resistant to conventional …
[HTML][HTML] Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression
YY Li, N Mukaida - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus (Pim)
family proteins that exhibit serine/threonine kinase activity. Similar to the other Pim kinases …
family proteins that exhibit serine/threonine kinase activity. Similar to the other Pim kinases …
[HTML][HTML] MicroRNAs associated with a good prognosis of acute myeloid leukemia and their effect on macrophage polarization
A Neaga, C Bagacean, A Tempescul, L Jimbu… - Frontiers in …, 2021 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with poor outcomes
despite very intensive therapeutic approaches. For the majority of patients which are unfit …
despite very intensive therapeutic approaches. For the majority of patients which are unfit …
PIM kinases: an overview in tumors and recent advances in pancreatic cancer
J Xu, T Zhang, T Wang, L You, Y Zhao - Future oncology, 2014 - Taylor & Francis
The PIM kinases represent a family of serine/threonine kinases, which is composed of three
different members (PIM1, PIM2 and PIM3). Aberrant expression of PIM kinases is observed …
different members (PIM1, PIM2 and PIM3). Aberrant expression of PIM kinases is observed …
Reduced miR-215 expression predicts poor prognosis in patients with acute myeloid leukemia
YX Wang, T Zhang, D Yang, D Yao… - Japanese Journal of …, 2016 - academic.oup.com
Objective Abnormal expression of microRNA-215 has been identified in a variety of solid
cancers. However, little is known about the expression pattern of microRNA-215 in acute …
cancers. However, little is known about the expression pattern of microRNA-215 in acute …
MicroRNA21 and the various types of myeloid leukemia
Myeloid leukemia (ML) is heterogeneous cancer classified by abnormal growth of myeloid
cells due to genetic aberrations and mutations. It is generally categorized by clonal …
cells due to genetic aberrations and mutations. It is generally categorized by clonal …