Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Transforming growth factor–β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …

The appearance and growth of malignant tumors is a complicated process that is regulated
by a number of genes. In recent years, studies have revealed that the transforming growth …

Macrophages hold a critical position in the pathogenesis of liver injury and repair, in which
their infiltrations is regarded as a main feature for both acute and chronic liver diseases. It is …

Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular
matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and …

Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating
liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised …

Background The incidence of intervertebral disc degeneration (IVDD) is a common
degenerative disease with inflammation, decreased autophagy, and progression of fibrosis …