Immune cell behaviour and dynamics in the kidney—insights from in vivo imaging

AR Kitching, MJ Hickey - Nature Reviews Nephrology, 2022 - nature.com
The actions of immune cells within the kidney are of fundamental importance in kidney
homeostasis and disease. In disease settings such as acute kidney injury, anti-neutrophil …

Microfluidics add-on technologies for single-cell analysis

M Khan, Y Bi, G Zhang, F Yin, Y Xie, L Lin… - TrAC Trends in Analytical …, 2023 - Elsevier
Microfluidics revolutionized single-cell analysis in a way that was impossible through
conventional methods. However, microfluidic is not a stand-alone technique and cannot …

Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry

F Bock, X Dong, S Li, OM Viquez, E Sha… - Science …, 2024 - science.org
Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …

[HTML][HTML] Seeing through the skin: Optical methods for visualizing transdermal drug delivery with microneedles

B Limcharoen, S Wanichwecharungruang… - Advanced Drug Delivery …, 2024 - Elsevier
Optical methods play a pivotal role in advancing transdermal drug delivery research,
particularly with the emergence of microneedle technology. This review presents a …

Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids

MFM Gerli, G Calà, MA Beesley, B Sina, L Tullie… - Nature Medicine, 2024 - nature.com
Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to
samples obtained from termination of pregnancies, hampering prenatal investigation of fetal …

Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

DJ Jafree, D Moulding, M Kolatsi-Joannou… - Elife, 2019 - elifesciences.org
Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific
lymphatic function. Little is known about lymphatics in the developing kidney, despite their …

Beyond a passive conduit: implications of lymphatic biology for kidney diseases

DJ Jafree, DA Long - Journal of the American Society of …, 2020 - journals.lww.com
The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and
cells from the renal interstitium. Through modulating immune responses and via crosstalk …

The biological significance and implications of planar cell polarity for nephrology

E Papakrivopoulou, DJ Jafree, CH Dean… - Frontiers in …, 2021 - frontiersin.org
The orientation of cells in two-dimensional and three-dimensional space underpins how the
kidney develops and responds to disease. The process by which cells orientate themselves …

Navigating across multi-dimensional space of tissue clearing parameters

SV Avilov - Methods and Applications in Fluorescence, 2021 - iopscience.iop.org
Optical tissue clearing refers to physico-chemical treatments which make thick biological
samples transparent by removal of refractive index gradients and light absorbing …

Deep learning applications for kidney histology analysis

P Pilva, R Bülow, P Boor - Current Opinion in Nephrology and …, 2024 - journals.lww.com
Deep learning offers great opportunities to improve quantitative and qualitative kidney
histology analysis for research and clinical nephropathology diagnostics. Although exciting …