Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

Over the last decades, incrementally improved xenograft mouse models, supporting the
engraftment and development of a human hemato-lymphoid system, have been developed …

Immunodeficient mice reconstituted with a human immune system represent a promising
tool for translational research as they may allow modeling and therapy of human diseases in …

Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …

Immunotherapy with checkpoint inhibitors opened new horizons in cancer treatment. Clinical
trials for novel immunotherapies or unexplored combination regimens either need years of …

Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …

With the increase in knowledge resulting from the sequencing of the human genome, the
genetic basis for the underlying differences in individuals, their diseases, and how they …

Humanized mice are a powerful tool for the study of human hematopoiesis and immune
function in vivo. However, the existing models cannot support robust adaptive immune …