Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

SR Doyle, A Tracey, R Laing, N Holroyd… - Communications …, 2020 - nature.com
Haemonchus contortus is a globally distributed and economically important gastrointestinal
pathogen of small ruminants and has become a key nematode model for studying …

Convergent evolution in a murine intestinal parasite rapidly created the TGM family of molecular mimics to suppress the host immune response

RM Maizels, SJ Newfeld - Genome biology and evolution, 2023 - academic.oup.com
Abstract The Transforming Growth Factor-β mimic (TGM) multigene family was recently
discovered in the murine intestinal parasite Heligmosomoides polygyrus. This family was …

Research progress and limitation analysis of RNA interference in Haemonchus contortus in China

B Hou, Y Hai, B Buyin, S Hasi - Frontiers in Veterinary Science, 2023 - frontiersin.org
Haemonchus contortus is a highly pathogenic and economically important parasitic
nematode that affects small ruminants worldwide. While omics studies hold great promise …

Assembly and Analysis of Haemonchus contortus Transcriptome as a Tool for the Knowledge of Ivermectin Resistance Mechanisms

DE Reyes-Guerrero, V Jiménez-Jacinto… - Pathogens, 2023 - mdpi.com
Haemonchus contortus (Hc) is an important parasitic nematode of small ruminants. In this
study we assembled the transcriptome of Hc as a model to contribute to the knowledge …

[HTML][HTML] Chromosome-contiguous genome for the Haecon-5 strain of Haemonchus contortus reveals marked genetic variability and enables the discovery of essential …

Y Zheng, ND Young, TL Campos, PK Korhonen… - International Journal for …, 2024 - Elsevier
Millions of livestock animals worldwide are infected with the haematophagous barber's pole
worm, Haemonchus contortus, the aetiological agent of haemonchosis. Despite the major …

Untargeted Multimodal Metabolomics Investigation of the Haemonchus contortus Exsheathment Secretome

N Palevich, PH Maclean, PM Candy, W Taylor… - Cells, 2022 - mdpi.com
In nematodes that invade the gastro-intestinal tract of the ruminant, the process of larval
exsheathment marks the transition from the free-living to the parasitic stages of these …

Comparative study of transcription profiles of the P-glycoprotein transporters of two Haemonchus contortus isolates: Susceptible and resistant to ivermectin

DE Reyes-Guerrero, M Cedillo-Borda… - Molecular and …, 2020 - Elsevier
The objective of this study was to analyze the mRNA transcription levels of ten functional
genes of P-glycoproteins (P-gp) in free life stages, eggs and infective larvae (L 3) and in …

Characterization of the Complete Mitochondrial Genomes of Two Sibling Species of Parasitic Roundworms, Haemonchus contortus and Teladorsagia circumcincta

N Palevich, PH Maclean, YJ Choi, M Mitreva - Frontiers in genetics, 2020 - frontiersin.org
Haemonchus contortus and Teladorsagia circumcincta are among the two most pathogenic
internal parasitic nematodes infecting small ruminants, such as sheep and goats, and are a …

Toward integrative 'omics of the barber's pole worm and related parasitic nematodes

G Ma, RB Gasser, T Wang, PK Korhonen… - Infection, Genetics and …, 2020 - Elsevier
Advances in nucleic acid sequencing, mass spectrometry and computational biology have
facilitated the identification, annotation and analysis of genes, transcripts, proteins and …

In silico analysis of two Haemonchus spp. serine protease peptides (S28) and their immunomodulatory activity in vitro

R Camas-Pereyra, GA Bautista-García, G Avila… - Molecular and …, 2023 - Elsevier
The aim of this study was to evaluate the in vitro immune modulation of two de novo
peptides with hypothetical identity to the serine protease family (S28) from Haemonchus …