Animal appendages require a proximodistal (PD) axis, which forms orthogonally from the
two main body axes, anteroposterior and dorsoventral. In this review, we discuss recent …

Notch signaling is an evolutionarily conserved pathway which functions between adjacent
cells to establish their distinct identities. Despite operating in a simple mechanism, Notch …

ABSTRACT A major factor driving stem cell decline is stem cell niche aging, but its
molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell …

Since Miller's morphological description, the Drosophila leg musculature and its formation
has not been revisited. Here, using a set of GFP markers and confocal microscopy, we …

In the Drosophila leg, activation of Notch leads to the establishment of the joints that
subdivide the appendage into segments. We find that mutations in bowl result in similar …

In Drosophila, Suppressor of deltex (Su (dx)) mutations display a wing vein gap phenotype
resembling that of Notch gain of function alleles. The Su (dx) protein may therefore act as a …

Apoptosis is a fundamental remodeling process for most tissues during development. In this
manuscript we examine a pro-apoptotic function for the Drosophila DNA binding protein Zfh …

The Notch signalling pathway appears to be ubiquitous in virtually all cell‐cell contacts in all
metazoan animals, and is best known and most throughout studied in Drosophila …

The development of the Drosophila leg is a good model to study processes of pattern
formation, cell death and segmentation. Such processes require the coordinate activity of …

The insect antenna and leg are considered homologous structures, likely to have arisen via
duplication and divergence from an ancestral limb. Consistent with this, the antenna and leg …