Pathophysiological aspects and therapeutic armamentarium of Alzheimer's disease: recent trends and future development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

[HTML][HTML] The effect of hypoxia on mesenchymal stem cell biology

M Ejtehadifar, K Shamsasenjan… - Advanced …, 2015 - ncbi.nlm.nih.gov
Although physiological and pathological role of hypoxia have been appreciated in
mammalians for decades however the cellular biology of hypoxia more clarified in the past …

let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3

O Ham, SY Lee, CY Lee, JH Park, J Lee… - Stem cell research & …, 2015 - Springer
Abstract Introduction Mesenchymal stem cells (MSCs) have therapeutic potential for the
repair of myocardial injury. The efficacy of MSC therapy for myocardial regeneration mainly …

The role of hypoxia-induced miR-210 in cancer progression

K Dang, KA Myers - International journal of molecular sciences, 2015 - mdpi.com
Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor
development and growth by promoting the formation of a neoplastic environment. The recent …

In vitro innovation of tendon tissue engineering strategies

MR Citeroni, MC Ciardulli, V Russo… - International journal of …, 2020 - mdpi.com
Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease

S Parvez - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is a multivariate and diversified disease and affects the most
sensitive areas of the brain, the cerebral cortex, and the hippocampus. AD is a progressive …

miRNAs as therapeutic tools in Alzheimer's disease

CY Lee, IS Ryu, JH Ryu, HJ Cho - International Journal of Molecular …, 2021 - mdpi.com
Alzheimer's disease (AD), an age-dependent, progressive neurodegenerative disorder, is
the most common type of dementia, accounting for 50–70% of all dementia cases. Due to …

Oxidative stress in mesenchymal stem cell senescence: regulation by coding and noncoding RNAs

R Vono, E Jover Garcia, G Spinetti… - Antioxidants & Redox …, 2018 - liebertpub.com
Abstract Significance: Mesenchymal stem cells (MSCs), adult stem cells with the potential of
differentiation into mesodermal lineages, play an important role in tissue homeostasis and …

[HTML][HTML] Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells

Y Jung, SK Park, D Kang, S Hwang, MH Kang… - Redox biology, 2020 - Elsevier
The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-
scale cell expansion prior to administration. However, the prolonged culture of hMSCs …

miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition

H Zheng, N Wang, L Li, L Ge, H Jia, Z Fan - International Journal of Oral …, 2021 - nature.com
Human dental pulp stem cells (DPSCs) have emerged as an important source of stem cells
in the tissue engineering, and hypoxia will change various innate characteristics of DPSCs …