ABC transporters play an essential role in the development of multidrug resistance and thus
are of interest in the context of anticancer therapy. However, MDR1, BCRP and MRP1 are …

Abstract P-glycoprotein (P-gp, encoded by the ABCB1 gene) and breast cancer resistance
protein (BCRP/ABCG2) are efflux multidrug resistance (MDR) transporters localized at the …

Objectives: To improve preclinical drug testing during pregnancy, we developed multiple
microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and …

Background Fetal inflammatory response mediated by the influx of immune cells and
activation of pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is …

Chorion trophoblasts (CTCs) and immune cell-enriched decidua (DECs) comprise the
maternal-fetal membrane interface called the chorio-decidual interface (CDi) which …

Oxidative stress (OS) and inflammation arising from cellular derangements at the fetal
membrane‐decidual interface (feto‐maternal interface [FMi]) is a major antecedent to …

Background Environmental exposure to toxicants is a major risk factor for spontaneous
preterm birth (PTB,< 37 weeks). Toxicants and drugs administered to patients are …

In recent years, Cannabis use/misuse for treating pregnancy-related symptoms and other
chronic conditions has increased among pregnant women, favored by decriminalization …

Introduction During pregnancy, the growth of the fetus is supported by the exchange of
nutrients, waste, and other molecules between maternal and fetal circulations in the utero …

The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …