Platelet-monocyte aggregates: molecular mediators of thromboinflammation

CC Rolling, TJ Barrett, JS Berger - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Platelets, key facilitators of primary hemostasis and thrombosis, have emerged as crucial
cellular mediators of innate immunity and inflammation. Exemplified by their ability to alter …

[HTML][HTML] G protein-coupled P2Y12 receptor is involved in the progression of neuropathic pain

L Ming, D Hu, C Zuo, W Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The pathological mechanism of neuropathic pain is complex, which seriously affects the
physical and mental health of patients, and its treatment is also difficult. The role of G protein …

[HTML][HTML] Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis

B Kocatürk, Y Lee, N Nosaka, M Abe, D Martinon… - JCI insight, 2023 - ncbi.nlm.nih.gov
Kawasaki disease (KD) is the leading cause of acquired heart disease among children.
Increased platelet counts and activation are observed during the course of KD, and elevated …

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial

JS Berger, MD Neal, LZ Kornblith, MN Gong… - JAMA network …, 2023 - jamanetwork.com
Importance Platelet activation is a potential therapeutic target in patients with COVID-19.
Objective To evaluate the effect of P2Y12 inhibition among critically ill patients hospitalized …

Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses

MA Sowa, H Sun, TT Wang, VW Virginio… - Basic to Translational …, 2024 - jacc.org
The authors investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and
platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or …

Platelets in Kawasaki disease: mediators of vascular inflammation

M Noval Rivas, B Kocatürk, BS Franklin… - Nature Reviews …, 2024 - nature.com
Kawasaki disease, a systemic vasculitis that affects young children and can result in
coronary artery aneurysms, is the leading cause of acquired heart disease among children …

Reflections on World Thrombosis Day 2024

A Rigby, M Albisetti, EJ Favaloro… - Thrombosis and …, 2025 - thieme-connect.com
Haemostasis join forces in a collaborative editorial to share and emphasize our commitment
to advancing research, education, and clinical practice, and reducing the impact of …

The significance of CD16+ monocytes in the occurrence and development of chronic thromboembolic pulmonary hypertension: insights from single-cell RNA …

M Chen, Q Wu, N Shao, X Lai, H Lin, M Chen… - Frontiers in …, 2024 - frontiersin.org
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious
pulmonary vascular disease characterized by residual thrombi in the pulmonary arteries and …

[HTML][HTML] Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

D Peng, S Sun, M Zhao, L Zhan, X Wang - Journal of Functional …, 2024 - mdpi.com
Nanomaterials have been extensively used in the biomedical field due to their unique
physical and chemical properties. They promise wide applications in the diagnosis …

microRNAs and thrombo-inflammation: relationship in sight

S Águila, R González-Conejero… - Current Opinion in …, 2024 - journals.lww.com
Targeting microRNAs is a promising therapeutic approach to control thrombosis in patients
with both infectious and noninfectious inflammatory diseases. Future research efforts should …