Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Cancer cells display altered cellular lipid metabolism, including disruption in endogenous
lipid synthesis, storage, and exogenous uptake for membrane biogenesis and functions …

Reprogramming of lipid metabolism has received increasing recognition as a hallmark of
cancer cells because lipid dysregulation and the alteration of related enzyme profiles are …

Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects
adolescent and young adults. It has high risk for relapse and over the last four decades no …

Background Accumulating evidence indicates that aberrant microRNA (miRNA) expression
contributes to osteosarcoma progression. This study aimed to elucidate the association …