[HTML][HTML] NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

S Li, Y Sun, M Song, Y Song, Y Fang, Q Zhang, X Li… - JCI insight, 2021 - ncbi.nlm.nih.gov
Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …

Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual …

MB Stone, ZS Yaseen, BJ Miller, K Richardville… - Bmj, 2022 - bmj.com
Objectives To characterize individual participant level response distributions to acute
monotherapy for major depressive disorder in randomized, placebo controlled trials …

National prescription patterns of antidepressants in the treatment of adults with major depression in the US between 1996 and 2015: a population representative …

Y Luo, Y Kataoka, EG Ostinelli, A Cipriani… - Frontiers in …, 2020 - frontiersin.org
Few studies have delineated the real-world, long-term trends of prescription patterns of
antidepressants for patients with major depressive disorder (MDD). This study aims to …

Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop

M Horowitz, M Wilcock - Drug and Therapeutics Bulletin, 2022 - dtb.bmj.com
In England, the prescribing of antidepressants, primarily the newer generation
antidepressant classes, has steadily increased over recent years. There is ongoing debate …

A systematic review and network meta-analysis of psychological, psychosocial, pharmacological, physical and combined treatments for adults with a new episode of …

I Mavranezouli, O Megnin-Viggars, H Pedder… - …, 2024 - thelancet.com
Background Various effective treatments for depression exist. We aimed to identify the most
effective first-line treatments for new episodes of less and more severe depression (defined …

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled …

G Lewis, L Duffy, A Ades, R Amos, R Araya… - The Lancet …, 2019 - thelancet.com
Background Depression is usually managed in primary care, but most antidepressant trials
are of patients from secondary care mental health services, with eligibility criteria based on …

Pragmatic precision psychiatry—a new direction for optimizing treatment selection

RC Kessler, A Luedtke - JAMA psychiatry, 2021 - jamanetwork.com
Importance Clinical trials have identified numerous prescriptive predictors of mental disorder
treatment response, ie, predictors of which treatments are best for which patients. However …

Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis

Q Zhang, B Chen, J Zhang, J Dong, J Ma, Y Zhang… - BMC psychiatry, 2023 - Springer
Accumulating studies have shown the effects of gut microbiota management tools in
improving depression. We conducted a meta-analysis to evaluate the effects of prebiotics …

Estimates of the minimal important difference to evaluate the clinical significance of antidepressants in the acute treatment of moderate-to-severe depression

MP Hengartner, M Plöderl - BMJ evidence-based medicine, 2022 - ebm.bmj.com
The efficacy of antidepressants in the acute treatment of moderate-to-severe depression
remains a controversial issue. The minimal important difference (MID) is relevant to judge …

The complex clinical response to selective serotonin reuptake inhibitors in depression: a network perspective

L Boschloo, F Hieronymus, A Lisinski… - Translational …, 2023 - nature.com
The clinical response to selective serotonin reuptake inhibitors (SSRIs) in depression takes
weeks to be fully developed and is still not entirely understood. This study aimed to …