De novo metalloprotein design
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …
and catalysis—in which the position and property of each ligand and metal are dictated by …
De novo protein design, a retrospective
IV Korendovych, WF DeGrado - Quarterly reviews of biophysics, 2020 - cambridge.org
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …
complex folds with precisely defined structural and dynamic properties. The rational design …
Catalysis and Electron Transfer in De Novo Designed Metalloproteins
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
Protein design: toward functional metalloenzymes
F Yu, VM Cangelosi, ML Zastrow, M Tegoni… - Chemical …, 2014 - ACS Publications
Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …
protein structure and function. The field of protein design has seen significant progress over …
De novo design of four-helix bundle metalloproteins: One scaffold, diverse reactivities
Conspectus De novo protein design represents an attractive approach for testing and
extending our understanding of metalloprotein structure and function. Here, we describe our …
extending our understanding of metalloprotein structure and function. Here, we describe our …
Engineering novel metalloproteins: design of metal-binding sites into native protein scaffolds
Y Lu, SM Berry, TD Pfister - Chemical reviews, 2001 - ACS Publications
Proteins play an essential role in biology. Whether it is in catalysis or molecular recognition,
proteins set a golden standard of efficiency and selectivity that few other natural or artificial …
proteins set a golden standard of efficiency and selectivity that few other natural or artificial …
Design and engineering of artificial oxygen-activating metalloenzymes
Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …
properties fulfilling the needs of practical applications. Progress in this field has recently …
De Novo Design of Helical Bundles as Models for Understanding Protein Folding and Function
De novo protein design has proven to be a powerful tool for understanding protein folding,
structure, and function. In this Account, we highlight aspects of our research on the design of …
structure, and function. In this Account, we highlight aspects of our research on the design of …
Sulfur and selenium antioxidants: Challenging radical scavenging mechanisms and developing structure–activity relationships based on metal binding
MT Zimmerman, CA Bayse, RR Ramoutar… - Journal of inorganic …, 2015 - Elsevier
Because sulfur and selenium antioxidants can prevent oxidative damage, numerous animal
and clinical trials have investigated the ability of these compounds to prevent the oxidative …
and clinical trials have investigated the ability of these compounds to prevent the oxidative …
Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual …
R Torres Martin de Rosales, R Tavaré… - Angewandte Chemie …, 2011 - Wiley Online Library
The synergistic combination of positron emission tomography (PET) and magnetic
resonance imaging (MRI) is likely to become the next generation of dual-modality scanners …
resonance imaging (MRI) is likely to become the next generation of dual-modality scanners …