A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

S Gheibi, K Kashfi, A Ghasemi - Biomedicine & pharmacotherapy, 2017 - Elsevier
Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

Metformin–A future therapy for neurodegenerative diseases: Theme: Drug discovery, development and delivery in Alzheimer's disease Guest Editor: Davide Brambilla

M Markowicz-Piasecka, J Sikora, A Szydłowska… - Pharmaceutical …, 2017 - Springer
Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease,
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …

Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease

V Pilipenko, K Narbute, J Pupure, IK Langrate… - European Journal of …, 2020 - Elsevier
The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose
metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent …

[HTML][HTML] Diabetes and hypertension: pivotal involvement of purinergic signaling

KP Reichert, MFV Castro, CE Assmann… - Biomedicine & …, 2021 - Elsevier
Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems
and frequently associated with severe clinical complications, such as diabetic …

Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis

F Karami, H Jamaati, N Coleman-Fuller, MS Zeini… - Pharmacological …, 2023 - Springer
Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways
involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for …

Metformin/Donepezil combination modulates brain antioxidant status and hippocampal endoplasmic reticulum stress in type 2 diabetic rats

TO Obafemi, OR Olasehinde, OA Olaoye… - Journal of Diabetes & …, 2020 - Springer
Purpose Diabetes mellitus is associated with perturbations in brain biochemical parameters
associated with dementia. This study aimed at comparing the effect of metformin and …

Metformin and its sulfenamide prodrugs inhibit human cholinesterase activity

M Markowicz-Piasecka, J Sikora… - Oxidative medicine …, 2017 - Wiley Online Library
The results of epidemiological and pathophysiological studies suggest that type 2 diabetes
mellitus (T2DM) may predispose to Alzheimer's disease (AD). The two conditions present …

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

M Markowicz-Piasecka, KM Huttunen… - Journal of Enzyme …, 2018 - Taylor & Francis
The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide
derivatives of metformin on the activity of human acetylcholinesterase (AChE) and …

Efficacy and safety of hypoglycemic drugs in improving cognitive function in patients with Alzheimer's disease and mild cognitive impairment: A systematic review and …

XC Wang, CL Chu, HC Li, K Lu, CJ Liu, YF Cai… - Frontiers in …, 2022 - frontiersin.org
Objective The purpose of this study was to compare the effects of oral hypoglycaemic drugs
(HDs) on cognitive function and biomarkers of mild cognitive impairment (MCI) and …

Dyslipidemia and hyperglycemia induce overexpression of Syndecan-3 in erythrocytes and modulate erythrocyte adhesion

SH Mallanna, RK Thimmulappa… - The Journal of …, 2024 - academic.oup.com
Erythrocytes are important vascular components that play vital roles in maintaining vascular
homeostasis, in addition to carrying oxygen. Previously, we reported that the changes in the …