Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Cancer cell invasion from primary tumors is mediated by a complex interplay between
cellular adhesions, actomyosin-driven contractility, and the physical characteristics of the …

A migrating cell is a molecular machine made of tens of thousands of short-lived and
interacting parts. Understanding migration means understanding the self-organization of …

Filopodia have a key role in sensing both chemical and mechanical cues in surrounding
extracellular matrix (ECM). However, quantitative understanding is still missing in the …

Various cues from the microenvironment in which cells live can regulate cellular functions. In
addition to biochemical cues, increasing evidence has demonstrated that mechanical cues …

Bone regeneration is strongly dependent on the capacity of cells to move in a 3D
microenvironment, where a large cascade of signals is activated. To improve the …

An integrative cell migration model incorporating focal adhesion (FA) dynamics,
cytoskeleton and nucleus remodeling, actin motor activity, and lamellipodia protrusion is …

Cell migration on a two-dimensional flat surface has been extensively studied and is
generally characterized by a front-protrusion–rear-contraction process. In a three …

Actin protrusion dynamics plays an important role in the regulation of three-dimensional (3D)
cell migration. Cells form protrusions that adhere to the surrounding extracellular matrix …