The chemistry of superacids has developed in the last two decades into a field of growing
interest and importance. Now available in a new expanded second edition, this definitive …

The role of cyclin-dependent kinases (CDKs) in regulating the transition of cell cycle steps
makes this class of enzymes a suitable target for cancer therapy. Three different generations …

The first direct use of carbon dioxide in the lactamization of alkenyl and heteroaryl C− H
bonds to synthesize important 2‐quinolinones and polyheterocycles in moderate to …

An 11-step, 8-pot synthesis of the antimalarial drug tafenoquine succinate was achieved in
42% overall yield using commercially available starting materials. Compared to the previous …

Quinolones continue to receive significant attention owing to their diverse range of biological
activities. They provide an important scaffold in anticancer, antibacterial and antiviral drug …

Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic
agents, and we adopted the drug design concept of scaffold hopping to replace the 2 …

It is known that 2-quinolones are broadly applicable chemical structures in medicinal and
agrochemical research as well as various functional materials. A number of current …

The superacid-promoted reactions of R-hydroxy and R-ketoamides have been studied.
Ionization of these compounds leads to varied aryl-substituted oxyindole products. In some …

Here we report an iron-complex-catalyzed synthesis of various mono-and di-substituted
quinolin-2 (1H)-ones achieved via the intramolecular acceptorless dehydrogenative …

A simple and cost-effective 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP)-mediated protocol
for the synthesis of β-oxo amides has been described by using amines and β-keto esters as …