Cancer remains the second leading cause of mortality worldwide, and overall cancer-related
deaths are increasing. Despite the survival benefit from early detection, screening has to …

Simple Summary Thyroid cancer remains a challenging malignancy, and it is difficultt to
scale appropriate monitoring and therapy. Monitoring of the outcomes of thyroid cancer …

Detection of microsatellite-instability in colonoscopy-obtained polyps, as well as in plasma-
circulating DNA, is frequently confounded by sensitivity issues due to co-existing excessive …

Breast cancer is a highly heterogeneous and dynamic disease, exhibiting unique somatic
alterations that lead to disease recurrence and resistance. Tumor biopsy and conventional …

Abstract BACKGROUND Cell-free DNA (cfDNA) diagnostics are emerging as a new
paradigm of disease monitoring and therapy management. The clinical utility of these …

The untested empirical medications exacerbated the development of multidrug-resistant
Mycobacterium tuberculosis (MDR-TB). Here, we develop a rapid and specific method …

PIK3CA is one of the two most frequently mutated genes in breast cancers, occurring in 30–
40% of cases. Four frequent 'hotspot'PIK3CA mutations (E542K, E545K, H1047R and …

Microsatellite instability (MSI), a phenotype displayed as deletions/insertions of repetitive
genomic sequences, has drawn great attention due to its application in cancer including …

The goal of this study was to develop a method for whole genome cell-free DNA (cfDNA)
methylation analysis in humans and mice with the ultimate goal to facilitate the identification …

BACKGROUND Although interest in droplet-digital PCR technology (ddPCR) for cell-free
circulating DNA (cfDNA) analysis is burgeoning, the technology is compromised by …