Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics

S Cho, A Wood, MR Bowlby - Current neuropharmacology, 2007 - ingentaconnect.com
Recent improvements in brain slice technology have made this biological preparation
increasingly useful for examining pathophysiology of brain diseases in a tissue context …

Derivatization trends in capillary electrophoresis

JCM Waterval, H Lingeman, A Bult… - ELECTROPHORESIS …, 2000 - Wiley Online Library
This survey gives an overview of recent derivatization protocols, starting from 1996, in
combination with capillary electrophoresis (CE). Derivatization is mainly used for enhancing …

In vivo monitoring of dopamine by microdialysis with 1 min temporal resolution using online capillary liquid chromatography with electrochemical detection

H Gu, EL Varner, SR Groskreutz, AC Michael… - Analytical …, 2015 - ACS Publications
Microdialysis is often applied to understanding brain function. Because neurotransmission
involves rapid events, increasing the temporal resolution of in vivo measurements is …

Time-resolved microdialysis for in vivo neurochemical measurements and other applications

KN Schultz, RT Kennedy - Annu. Rev. Anal. Chem., 2008 - annualreviews.org
Monitoring changes in chemical concentrations over time in complex environments is
typically performed using sensors and spectroscopic techniques. Another approach is to …

An in vitro blood–brain barrier model: Cocultures between endothelial cells and organotypic brain slice cultures

S Duport, F Robert, D Muller, G Grau… - Proceedings of the …, 1998 - National Acad Sciences
This communication describes a novel in vitro blood–brain barrier (BBB) model: organotypic
slice cultures from the central nervous system were overlaid on endothelial cell monolayers …

Homocyclic o‐dicarboxaldehydes: Derivatization reagents for sensitive analysis of amino acids and related compounds by capillary and microchip electrophoresis

A Celá, Z Glatz - Electrophoresis, 2020 - Wiley Online Library
Amino acids are essential compounds for living organisms, and their determination in
biological fluids is crucial for the clinical analysis and diagnosis of many diseases. However …

Evaluation of hydrogel-coated glutamate microsensors

WH Oldenziel, G Dijkstra, TIFH Cremers… - Analytical …, 2006 - ACS Publications
Glutamate microsensors form a promising analytical tool for monitoring neuronally derived
glutamate directly in the brain. However, when a microsensor is implanted in brain tissue …

The use of naphthalene‐2, 3‐dicarboxaldehyde for the analysis of primary amines using high‐performance liquid chromatography and capillary electrophoresis

G Rammouz, M Lacroix, JC Garrigues… - Biomedical …, 2007 - Wiley Online Library
This paper reviews analytical methods, instrumental developments and applications for
derivatization of primary amines with naphthalene‐2, 3‐dicarboxaldehyde using …

Monitoring extracellular glutamate in hippocampal slices with a microsensor

WH Oldenziel, M Van der Zeyden, G Dijkstra… - Journal of neuroscience …, 2007 - Elsevier
The direct local assessment of glutamate in brain slices may improve our understanding of
glutamatergic neurotransmission significantly. However, an analytical technique that …

Coupling on-line brain microdialysis, precolumn derivatization and capillary electrophoresis for routine minute sampling of O-phosphoethanolamine and excitatory …

F Robert, L Bert, S Parrot, L Denoroy, L Stoppini… - … of Chromatography A, 1998 - Elsevier
In previous papers, we described the analysis of excitatory amino acids (EAAs) and
catecholamines in microdialysis samples using capillary electrophoresis with laser-induced …