Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …
their native functional states into intractable amyloid aggregates. This phenomenon is …
Protein aggregation–mechanisms, detection, and control
W Wang, CJ Roberts - International journal of pharmaceutics, 2018 - Elsevier
Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …
development and commercialization of successful protein-based drug products because of …
[HTML][HTML] Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics
AS Bhale, K Venkataraman - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …
Familial amyloid polyneuropathy
V Planté-Bordeneuve, G Said - The Lancet Neurology, 2011 - thelancet.com
Familial amyloid polyneuropathies (FAPs) are a group of life-threatening multisystem
disorders transmitted as an autosomal dominant trait. Nerve lesions are induced by deposits …
disorders transmitted as an autosomal dominant trait. Nerve lesions are induced by deposits …
Apolipoprotein A‐I: the dual face of a protein
Conformational plasticity and flexibility are key structural features of Apo AI in lipid
metabolism. Amyloidogenic single point mutations, associated with incurable familial …
metabolism. Amyloidogenic single point mutations, associated with incurable familial …
The crystal structure of the C-terminal truncated apolipoprotein AI sheds new light on amyloid formation by the N-terminal fragment
O Gursky, X Mei, D Atkinson - Biochemistry, 2012 - ACS Publications
Apolipoprotein AI (apoA-I) is the main protein of plasma high-density lipoproteins (HDL, or
good cholesterol) that remove excess cell cholesterol and protect against atherosclerosis. In …
good cholesterol) that remove excess cell cholesterol and protect against atherosclerosis. In …
Amyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein AI generates a new aggregation-prone segment that promotes nucleation through entropic …
N Namba, T Ohgita, H Tamagaki-Asahina… - Scientific reports, 2023 - nature.com
The N-terminal fragment of apolipoprotein AI (apoA-I), comprising residues 1–83, contains
three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously …
three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously …
Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions
K Yanagi, M Ashizaki, H Yagi, K Sakurai, YH Lee… - Journal of Biological …, 2011 - ASBMB
Although amyloid fibrils deposit with various proteins, the comprehensive mechanism by
which they form remains unclear. We studied the formation of fibrils of human islet amyloid …
which they form remains unclear. We studied the formation of fibrils of human islet amyloid …
Amyloidogenic mutations in human apolipoprotein A‐I are not necessarily destabilizing–a common mechanism of apolipoprotein A‐I misfolding in familial amyloidosis …
M Das, X Mei, S Jayaraman, D Atkinson… - The FEBS …, 2014 - Wiley Online Library
High‐density lipoproteins and their major protein, apolipoprotein A‐I (apoA‐I), remove
excess cellular cholesterol and protect against atherosclerosis. However, in acquired …
excess cellular cholesterol and protect against atherosclerosis. However, in acquired …
A new prion disease: relationship with central and peripheral amyloidoses
S Mead, MM Reilly - Nature Reviews Neurology, 2015 - nature.com
Prion diseases are typically recognized as rapidly progressive dementing illnesses that also
feature myoclonus and cerebellar ataxia. Several families have now been described with a …
feature myoclonus and cerebellar ataxia. Several families have now been described with a …