Respiratory syncytial virus infection and novel interventions

AC Langedijk, LJ Bont - Nature Reviews Microbiology, 2023 - nature.com
The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in
young children and older adults has gained increased recognition in recent years. Recent …

Recent progress toward the discovery of small molecules as novel anti-respiratory syncytial virus agents

T Felicetti, C Sarnari, R Gaito, O Tabarrini… - Journal of Medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …

Direct-acting antivirals for RSV treatment, a review

B Bonneux, E Jacoby, M Ceconi, K Stobbelaar… - Antiviral Research, 2024 - Elsevier
Respiratory syncytial virus (RSV) causes respiratory disease and complications in infants,
the elderly and the immunocompromised. While three vaccines and two prophylactic …

New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021 - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

All Eyes on the Prefusion-Stabilized F Construct, but Are We Missing the Potential of Alternative Targets for Respiratory Syncytial Virus Vaccine Design?

S Schaerlaekens, L Jacobs, K Stobbelaar, P Cos… - Vaccines, 2024 - mdpi.com
Respiratory Syncytial Virus (RSV) poses a significant global health concern as a major
cause of lower respiratory tract infections (LRTIs). Over the last few years, substantial efforts …

Plant-derived antimicrobial peptides as potential antiviral agents in systemic viral infections

N Mammari, Y Krier, Q Albert, M Devocelle… - Pharmaceuticals, 2021 - mdpi.com
Numerous studies have led to a better understanding of the mechanisms of action of viruses
in systemic infections for the development of prevention strategies and very promising …

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

VA Kleiner, T O. Fischmann, JA Howe… - Communications …, 2023 - nature.com
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …

Pathogenicity and virulence of human respiratory syncytial virus: Multifunctional nonstructural proteins NS1 and NS2

TN Merritt, J Pei, DW Leung - Virulence, 2023 - Taylor & Francis
Human respiratory syncytial virus (hRSV) is a major cause of acute lower respiratory tract
infections in children under the age of two as well as in the elderly and …

Non-cellular layers of the respiratory tract: protection against pathogens and target for drug delivery

E Fröhlich - Pharmaceutics, 2022 - mdpi.com
Epithelial barriers separate the human body from the environment to maintain homeostasis.
Compared to the skin and gastrointestinal tract, the respiratory barrier is the thinnest and …

Investigating the antiviral activity of Erigeron annuus (L.) pers extract against RSV and examining its active components

X Zhang, S Zhou, H Yu, Y Zhu, L Zhang, F jv Niu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The plants in the genus Erigeron are known to exhibit
antiviral activities, including those against the respiratory syncytial virus (RSV). In traditional …