Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications
Glycans cover the surfaces of all mammalian cells through a process called glycosylation.
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …
Glycans as key checkpoints of T cell activity and function
The immune system is highly controlled and fine-tuned by glycosylation, through the
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …
A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan
J Gaifem, CS Rodrigues, F Petralia, I Alves… - Nature …, 2024 - nature.com
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
[HTML][HTML] Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases
X Verhelst, AM Dias, JF Colombel, S Vermeire… - Gastroenterology, 2020 - Elsevier
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate
their structure and function. Glycans modify proteins required for regulation of immune cells …
their structure and function. Glycans modify proteins required for regulation of immune cells …
[HTML][HTML] Precision medicine in inflammatory bowel disease: concept, progress and challenges
Crohn's disease and ulcerative colitis are increasingly prevalent, relapsing and remitting
inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their …
inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their …
[HTML][HTML] Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation
Glycans are essential cellular components that facilitate a range of critical functions
important for tissue development and mucosal homeostasis. Furthermore, specific …
important for tissue development and mucosal homeostasis. Furthermore, specific …
Anti-TL1A antibody PF-06480605 safety and efficacy for ulcerative colitis: a phase 2a single-arm study
S Danese, M Klopocka, EJ Scherl, J Romatowski… - Clinical …, 2021 - Elsevier
Background & Aims An immune component of inflammatory bowel disease is up-regulated
tumor necrosis factor-like ligand 1A (TL1A). Anti-TL1A antibodies such as PF-06480605, a …
tumor necrosis factor-like ligand 1A (TL1A). Anti-TL1A antibodies such as PF-06480605, a …
Current and emerging biomarkers for ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic illness requiring lifelong management that
could be enhanced by personalizing care using biomarkers. Areas covered The main …
could be enhanced by personalizing care using biomarkers. Areas covered The main …
The role of glycosylation in clinical allergy and immunology
RC Hale, D Morais, J Chou, SR Stowell - Journal of Allergy and Clinical …, 2024 - Elsevier
While glycans are among the most abundant macromolecules on the cell with widespread
functions, their role in immunity has historically been challenging to study. This is in part due …
functions, their role in immunity has historically been challenging to study. This is in part due …
Anti-TNF biologicals enhance the anti-inflammatory properties of IgG N-glycome in Crohn's disease
Crohn's disease (CD) is a chronic inflammation of the digestive tract that significantly impairs
patients' quality of life and well-being. Anti-TNF biologicals revolutionised the treatment of …
patients' quality of life and well-being. Anti-TNF biologicals revolutionised the treatment of …