Background The joint committee of the Japanese Society of Intensive Care
Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …

Polymorphonuclear neutrophils form a primary line of defense against bacterial infections
using complementary oxidative and non-oxidative pathways to destroy phagocytized …

Objective: Neutrophil elastase is believed to be an important mediator of acute lung injury.
Sivelestat (ONO-5046, Elaspol) is a small molecular weight inhibitor of neutrophil elastase …

Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the
monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its …

VEGFs and their receptors have been implicated in the regulation of vascular permeability in
many organ systems, including the lung. Increased permeability and interstitial and …

Abstract This review describes Protease Inhibitors (PIs) which target or inhibit proteases,
protein digesting enzymes. These proteases play a crucial task in many biological events …

Diaryl esters of α-aminophosphonates are a group of low molecular weight inhibitors of
serine proteases. For over 30 years these molecules have captured the attention of …

Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung
scarring, with death from respiratory failure within 2–4 years unless lung transplantation is …