Isolation and use of solid tumor stem cells
(57) ABSTRACT A Small percentage of cells within an established Solid tumor have the
properties of Stem cells. These Solid tumor Stem cells give rise both to more tumor Stem …
properties of Stem cells. These Solid tumor Stem cells give rise both to more tumor Stem …
Compositions and methods for treating and diagnosing cancer
MF Clarke, T Hoey, X Wang, S Dylla, A Gurney… - US Patent …, 2010 - Google Patents
2007-05-21 Assigned to ONCOMED PHARMACEUTICALS, INC. reassignment ONCOMED
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Complementing cell lines
R Vogels, MJE Havenga, M Mehtali - US Patent 6,974,695, 2005 - Google Patents
A packaging cell line capable of complementing recombinant adenoviruses based on
serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived …
serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived …
Determining the capability of a test compound to affect solid tumor stem cells
MF Clarke, SJ Dylla, S Satyal - US Patent 8,044,259, 2011 - Google Patents
A small percentage of cells within an established solid tumor have the properties of stem
cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority …
cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority …
Methods of use for an antibody against human frizzled receptors 1, 2. 5, 7 or 8
AL Gurney, AK Sato, FT Axelrod, TC Hoey… - US Patent …, 2013 - Google Patents
2011-09-09 Assigned to ONCOMED PHARMACEUTICALS, INC. reassignment ONCOMED
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Non-natural ribonuclease conjugates as cytotoxic agents
LE Strong, PA Leland, T Burke - US Patent 8,470,315, 2013 - Google Patents
The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
Compositions and methods for treating and diagnosing cancer
MF Clarke, X Wang, JA Lewicki, AL Gurney - US Patent 7,939,263, 2011 - Google Patents
The present invention relates to compositions and methods for treating, characterizing, and
diagnosing cancer. In particular, the present invention provides gene expression profiles …
diagnosing cancer. In particular, the present invention provides gene expression profiles …
Compositions and methods for treating and diagnosing cancer
MF Clarke, T Hoey, X Wang, S Dylla… - US Patent App. 12 …, 2010 - Google Patents
2009-12-31 Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN reassignment
THE REGENTS OF THE UNIVERSITY OF MICHIGAN ASSIGNMENT OF ASSIGNORS …
THE REGENTS OF THE UNIVERSITY OF MICHIGAN ASSIGNMENT OF ASSIGNORS …
Compositions and methods for diagnosing and treating cancer
A Gurney, J Lewicki, S Satyal, T Hoey - US Patent 9,850,311, 2017 - Google Patents
6, 159, 750 A 6, 180, 370 B1 6, 190, 876 B1 6, 197, 523 B1 6, 198, 107 B1 6, 207, 147 B1 6,
218, 166 B1 6, 252, 050 B1 6, 262, 025 B1 6, 353, 150 B1 6, 379, 925 B1 6, 380, 362 B1 6 …
218, 166 B1 6, 252, 050 B1 6, 262, 025 B1 6, 353, 150 B1 6, 379, 925 B1 6, 380, 362 B1 6 …
Deleted adenovirus vectors and methods of making and administering the same
A Amalfitano, YT Chen, H Hu - US Patent 6,328,958, 2001 - Google Patents
approaches to accomplishing gene therapy has been the use of recombinant viral vectors
which have been genetically engineered to carry a desired transgene. These viral-based …
which have been genetically engineered to carry a desired transgene. These viral-based …