SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

I Colmenero, C Santonja… - British journal of …, 2020 - academic.oup.com
Summary Background Chilblains ('COVID toes') are being seen with increasing frequency in
children and young adults during the COVID‐19 pandemic. Detailed histopathological …

Pernio (chilblains), SARS-CoV-2, and COVID toes unified through cutaneous and systemic mechanisms

MA Cappel, JA Cappel, DA Wetter - Mayo Clinic Proceedings, 2021 - Elsevier
Pernio or chilblains is characterized by erythema and swelling at acral sites (eg, toes and
fingers), typically triggered by cold exposure. Clinical and histopathologic features of pernio …

Chilblain-like acral lesions during the COVID-19 pandemic (“COVID toes”): histologic, immunofluorescence, and immunohistochemical study of 17 cases

J Kanitakis, C Lesort, M Danset, D Jullien - Journal of the American …, 2020 - Elsevier
Background During the coronavirus disease 2019 pandemic, several acral chilblain-like
lesions were observed in young patients with suspected, but mostly unconfirmed, infection …

A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain‐like lesions: lights and shadows on the relationship with …

M El Hachem, A Diociaiuti, C Concato… - Journal of the …, 2020 - Wiley Online Library
Background Acral chilblain‐like lesions are being increasingly reported during COVID‐19
pandemic. However, only few patients proved positivity for SARS‐CoV‐2 infection. The …

Chilblains in immune-mediated inflammatory diseases: a review

S Dubey, N Joshi, O Stevenson, C Gordon… - …, 2022 - academic.oup.com
Chilblains were first described over a hundred years ago as cutaneous inflammatory
lesions, typically on the digits, occurring on cold exposure. Chilblains can be primary, or …

Clinical characteristics, etiologic associations, laboratory findings, treatment, and proposal of diagnostic criteria of pernio (chilblains) in a series of 104 patients at …

JA Cappel, DA Wetter - Mayo Clinic Proceedings, 2014 - Elsevier
Objective To further characterize the clinical features, etiologic associations, laboratory
findings, and treatment of pernio. Patients and Methods This is a retrospective review of …

Raynaud's phenomenon and related vasospastic disorders

E Choi, S Henkin - Vascular Medicine, 2021 - journals.sagepub.com
Raynaud's phenomenon, which is characterized by episodic digital pallor, cyanosis and
rubor upon exposure to cold environment or to stress, is relatively common, although the …

Chilblains

A Nyssen, F Benhadou, M Magnée, J André… - Vasa, 2019 - econtent.hogrefe.com
Idiopathic chilblain is a relatively common yet poorly recognized acrosyndrome. This
literature review aims to better understand and draw attention to this disorder. Chilblain is a …

A clinicopathological description of COVID‐19‐induced chilblains (COVID‐toes) correlated with a published literature review

A Kolivras, C Thompson, I Pastushenko… - Journal of cutaneous …, 2022 - Wiley Online Library
Background The abundance of publications of COVID‐19‐induced chilblains has resulted in
a confusing situation. Methods This is a prospective single‐institution study from 15 March to …

Cutaneous manifestations of lupus erythematosus: a practical clinicopathological review for pathologists

C Bitar, TD Menge, MP Chan - Histopathology, 2022 - Wiley Online Library
Accurate diagnosis of connective tissue diseases is often challenging, and relies upon
careful correlation between clinical and histopathological features, direct …