Antipsychotics, metabolic adverse effects, and cognitive function in schizophrenia

NE MacKenzie, C Kowalchuk, SM Agarwal… - Frontiers in …, 2018 - frontiersin.org
Cognitive impairment is a core symptom domain of schizophrenia. The effect of
antipsychotics, the cornerstone of treatment in schizophrenia, on this domain is not fully …

Metabolic side effects of antipsychotic drug treatment–pharmacological mechanisms

GP Reynolds, SL Kirk - Pharmacology & therapeutics, 2010 - Elsevier
Obesity and metabolic syndrome, with increased risk of eventual cardiovascular disease
and type II diabetes, are significant problems for patients receiving antipsychotic drugs and …

Antipsychotic drugs and obesity

CU Correll, T Lencz, AK Malhotra - Trends in molecular medicine, 2011 - cell.com
Mechanisms underlying antipsychotic cardiometabolic adverse effects are incompletely
understood. This hampers the identification of high-risk patients, low-risk antipsychotics and …

Systematic review of early cardiometabolic outcomes of the first treated episode of psychosis

DL Foley, KI Morley - Archives of general psychiatry, 2011 - jamanetwork.com
Objectives: To assess the methods and reporting of cardiometabolic outcome studies of the
first treated episode of psychosis, review key findings, and suggest directions for future …

Effects of antipsychotic medications on appetite, weight, and insulin resistance

C Deng - Endocrinology and Metabolism Clinics, 2013 - endo.theclinics.com
Mental disorders are the greatest overall cause of disability. 1 Antipsychotic drugs (APDs)
are the most widely prescribed medications and are used frequently to control various …

Atypical antipsychotic-induced weight gain: insights into mechanisms of action

JL Roerig, KJ Steffen, JE Mitchell - CNS drugs, 2011 - Springer
Prescriptions for second-generation antipsychotics (SGAs) have surpassed those for first-
generation agents in the treatment of schizophrenia and bipolar disorder. While SGAs have …

Potential mechanisms of atypical antipsychotic-induced metabolic derangement: clues for understanding obesity and novel drug design

R Coccurello, A Moles - Pharmacology & therapeutics, 2010 - Elsevier
Beside the therapeutic improvement over first-generation antipsychotics, the fact that
prescription of atypical agents is also associated to the emergence of severe metabolic …

Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course

S Gebhardt, M Haberhausen… - Journal of psychiatric …, 2009 - Elsevier
OBJECTIVE: To explore the impact of premorbid and baseline body mass indices (BMIs) as
well as BMI of patient's parents and associated variables on the prediction of antipsychotic …

Antipsychotic switching for people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

A Mukundan, G Faulkner, T Cohn… - Cochrane Database …, 2010 - cochranelibrary.com
Background Weight gain is common for people with schizophrenia and this has serious
implications for a patient's health and well being. Switching strategies have been …

Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor

K Weston-Green, XF Huang, C Deng - CNS drugs, 2013 - Springer
Second generation antipsychotics (SGAs) are widely prescribed to treat various disorders,
most notably schizophrenia and bipolar disorder; however, SGAs can cause abnormal …