Progress and prospect: Biosynthesis of plant natural products based on plant chassis

J Lin, X Yin, Y Zeng, X Hong, S Zhang, B Cui… - Biotechnology …, 2023 - Elsevier
Plant-derived natural products are a specific class of active substances with numerous
applications in the medical, energy, and industrial fields. Many of these substances are in …

Prenylation: a critical step for biomanufacturing of prenylated aromatic natural products

T An, X Feng, C Li - Journal of Agricultural and Food Chemistry, 2023 - ACS Publications
Prenylated aromatic natural products (PANPs) have received much attention due to their
biomedical benefits for human health. The prenylation of aromatic natural products (ANPs) …

New aspects of microbial vitamin K2 production by expanding the product spectrum

Z Zhang, L Liu, C Liu, Y Sun, D Zhang - Microbial Cell Factories, 2021 - Springer
Abstract Vitamin K2 (menaquinone, MK) is an essential lipid-soluble vitamin with critical
roles in blood coagulation and bone metabolism. Chemically, the term vitamin K2 …

Advances in regulating vitamin K2 production through metabolic engineering strategies

Y Liu, J Wang, J Huang, X Li, Y Chen, K Liu… - World Journal of …, 2024 - Springer
Abstract Vitamin K2 (menaquinone, VK2, MK) is an essential lipid-soluble vitamin that plays
critical roles in inhibiting cell ferroptosis, improving blood clotting, and preventing …

Dual-sgRNA CRISPRa System for Enhanced MK-7 Production and Salmonella Infection Mitigation in Bacillus subtilis natto Applied to Caco-2 Cells

C Liao, J Cui, M Gao, B Wang, K Ito… - Journal of Agricultural …, 2024 - ACS Publications
This study optimized the menaquinone-7 (MK-7) synthetic pathways in Bacillus subtilis (B.
subtilis) natto NB205, a strain that originated from natto, to enhance its MK-7 production …

Advances in Enhanced Menaquinone-7 Production From Bacillus subtilis

C Liao, H Ayansola, Y Ma, K Ito, Y Guo… - … in Bioengineering and …, 2021 - frontiersin.org
The production of nutraceutical compounds through biosynthetic approaches has received
considerable attention in recent years. For example, Menaquinone-7 (MK-7), a sub-type of …

Synthetic biology for sustainable food ingredients production: recent trends

KB Arun, AN Anoopkumar, R Sindhu, P Binod… - Systems Microbiology …, 2023 - Springer
Problems with food security result from increased population, global warming, and decrease
in cultivable land. With the advancements in synthetic biology, microbial synthesis of food is …

Comparison of different fermentation processes for the vitamin K2 (Menaquinone-7) production by a novel Bacillus velezensis ND strain

C Zhao, Y Wan, G Tang, Q Jin, H Zhang, Z Xu - Process Biochemistry, 2021 - Elsevier
In this study, a novel MK-7 producing bacterial strain, Bacillus velezensis ND, was isolated
and characterized. Multiple low-cost substrates were used in Bacillus velezensis ND culture …

Adaptive laboratory evolution for improved tolerance of vitamin K in Bacillus subtilis

X Ding, Z Zheng, G Zhao, L Wang, H Wang… - Applied Microbiology and …, 2024 - Springer
Abstract Menaquinone-7 (MK-7), a subtype of vitamin K2 (VK2), assumes crucial roles in
coagulation function, calcium homeostasis, and respiratory chain transmission. The …

Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism of Bacillus subtilis natto

X Chen, C Shang, H Zhang, C Sun, G Zhang… - Frontiers in …, 2022 - frontiersin.org
Menaquinone-7 (MK-7) is an important vitamin K2, synthesized from the menaquinone
parent ring and seven isoprene side chains. Presently, the synthesis of MK-7 stimulated by …