Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In
clinical practice, stable fracture fixation associated with autologous iliac crest bone graft …

Fracture healing is a complex, multistep process that is highly sensitive to mechanical
signaling. To optimize repair, surgeons prescribe immediate weight-bearing as-tolerated …

In newborn humans, and up to approximately 2 y of age, calvarial bone defects can naturally
regenerate. This remarkable regeneration potential is also found in newborn mice and is …

Neural crest-derived mesenchymal stem cells (MSCs) are known to play an essential
function during tooth and skeletal development. PRX1+ cells constitute an important MSC …

Injuries that heal by fibrosis can compromise organ function and increase patient morbidity.
The oral mucosal barrier has a high regenerative capacity with minimal scarring, but the …

Insufficient bone fracture repair represents a major clinical and societal burden and novel
strategies are needed to address it. Our data reveal that the transforming growth factor-β …

Postnatal intramembranous bone regeneration plays an important role during a wide variety
of musculoskeletal regeneration processes such as fracture healing, joint replacement and …

ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

Bone defect (BD) caused by trauma, infection, congenital defects, or neoplasia is a major
cause of physical limitation. Distraction osteogenesis (DO) is a highly effective procedure for …

The bone exhibits remarkable ability of self-repair without fibrous scars. It is believed that the
robust regenerative capacity comes from tissue-resident stem cells, such as the skeletal …