Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …

Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and
environmental factors, poses a significant risk for the development of coronary artery …

The Rpd3S complex plays a pivotal role in facilitating local histone deacetylation in the
transcribed regions to suppress intragenic transcription initiation. Here, we present the cryo …

The RNA polymerase II carboxy-terminal domain (CTD) consists of conserved heptapeptide
repeats that can be phosphorylated to influence distinct stages of the transcription cycle …

Histone deacetylases (HDACs) are enzymes that remove acetyl groups from ɛ-amino of
histone, and their involvement in the development and progression of cancer disorders …

Cryptic transcription refers to the unintended expression of non-canonical sites within the
genome, producing aberrant RNA and proteins that may disrupt cellular functions. In this …

Histone deacylases are erasers of N ε-acyl-lysine post-translational modifications and have
been targeted for decades for the treatment of cancer, neurodegeneration and other …

The Rpd3S histone deacetylase complex suppresses cryptic initiation and maintains
genomic integrity by deacetylating transcribed nucleosomes subsequent to RNA Pol II …

The sliding clamp is an integral protein in DNA replication and repair, where it increases the
speed of DNA synthesis and serves as a scaffold for repair proteins. Since the sliding clamp …