Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Objective: Oxygen is vital during critical illness, but hyperoxia may harm patients. Our aim
was to systematically evaluate the methodology and findings of cohort studies investigating …

Introduction The safety of arterial hyperoxia is under increasing scrutiny. We performed a
systematic review of the literature to determine whether any association exists between …

This review summarizes the (patho)-physiological effects of ventilation with high FiO 2 (0.8–
1.0), with a special focus on the most recent clinical evidence on its use for the management …

Introduction The aim of this study was to investigate whether in-hospital mortality was
associated with the administered fraction of oxygen in inspired air (FiO 2) and achieved …

Oxygen administration is uniformly used in emergency and intensive care medicine and has
life-saving potential in critical conditions. However, excessive oxygenation also has …

Background Aim of the study was to compare the short-term effects of oxygen therapy via a
high-flow nasal cannula (HFNC) on functional and subjective respiratory parameters in …

Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

Endoplasmic reticulum (ER) stress that disrupts ER function can occur in response to a wide
variety of cellular stress factors leads to the accumulation of unfolded and misfolded proteins …

Purpose Early hyperoxia may be an independent risk factor for mortality in mechanically
ventilated intensive care unit (ICU) patients. We examined the relationship between early …