S phingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …

Human pathologies such as Alzheimer's disease, type 2 diabetes-induced insulin
resistance, cancer, and cardiovascular diseases have altered lipid homeostasis. Among …

Sphingolipids are a ubiquitous class of lipids present in a variety of organisms including
eukaryotes and bacteria. In the last two decades, research has focused on characterizing …

Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …

Microvilli are conventionally regarded as an extension of the small intestinal absorptive
surface, but they are also, as latterly discovered, a launching pad for brush border digestive …

Sphingolipids are abundant in the microvillar membrane of intestinal epithelial cells where
they are essential for structural integrity and may act as receptors for toxins, virus and …

Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

Milk polar lipids provide choline, ethanolamine, and polyunsaturated fatty acids, which are
needed for the growth and plasticity of the tissues in a suckling child. They may also inhibit …

Sphingomyelin (SM), glycosphingolipids, and gangliosides are important polar lipids in the
milk fat globule membrane but are not found in standard milk replacement formulas …

Colorectal cancer is one of the major causes of death in the western world. Despite
increasing knowledge of the molecular signaling pathways implicated in colon cancer …