Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions

B Samra, E Jabbour, F Ravandi, H Kantarjian… - Journal of hematology & …, 2020 - Springer
Recent years have witnessed major advances that have improved outcome of adults with
acute lymphoblastic leukemia (ALL). The emergence of the concept of measurable residual …

The genomic landscape of pediatric acute lymphoblastic leukemia and precision medicine opportunities

TH Tran, SP Hunger - Seminars in cancer biology, 2022 - Elsevier
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and constitutes
approximately 25% of cancer diagnoses among children under the age of 15 (Howlader et …

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

ARM Almeida, JL Neto, A Cachucho, M Euzébio… - Nature …, 2021 - nature.com
Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether
acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger …

Philadelphia chromosome–like acute lymphoblastic leukemia

CH Pui, KG Roberts, JJ Yang, CG Mullighan - Clinical Lymphoma Myeloma …, 2017 - Elsevier
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is a recently
described B-cell precursor ALL with a gene expression profile and a high frequency of IKZF1 …

Optimizing the treatment of acute lymphoblastic leukemia in younger and older adults: new drugs and evolving paradigms

NJ Short, H Kantarjian, E Jabbour - Leukemia, 2021 - nature.com
In the past decade, the available treatments for patients with acute lymphoblastic leukemia
(ALL) have rapidly expanded, in parallel with an increased understanding of the genomic …

The journey to CAR T cell therapy: the pediatric and young adult experience with relapsed or refractory B-ALL

G Hucks, SR Rheingold - Blood cancer journal, 2019 - nature.com
Outcomes of pediatric and young adult patients diagnosed with acute lymphoblastic
leukemia (ALL) have improved significantly in the past few decades. Treatment advances …

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies

CEJ Downes, BJ McClure, DP McDougal… - Frontiers in Cell and …, 2022 - frontiersin.org
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …

Children's Oncology Group blueprint for research: Acute lymphoblastic leukemia

EA Raetz, D Bhojwani, M Devidas, L Gore… - Pediatric Blood & …, 2023 - Wiley Online Library
Cure rates for acute lymphoblastic leukemia (ALL), the most common childhood cancer have
steadily improved over the past five decades. This is due to intensifying systemic therapy …

Targeting mTOR in acute lymphoblastic leukemia

C Simioni, AM Martelli, G Zauli, E Melloni, LM Neri - Cells, 2019 - mdpi.com
Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …

Poverty and relapse risk in children with acute lymphoblastic leukemia: a Children's Oncology Group study AALL03N1 report

A Wadhwa, Y Chen, L Hageman… - Blood, The Journal …, 2023 - ashpublications.org
The association between individual-level poverty and relapse in children receiving
maintenance treatment for acute lymphoblastic leukemia (ALL) remains unclear. In a …