SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain
multiple protein-binding domains. These proteins are essential for signalling downstream of …

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of
serine/threonine kinases. MAP4Ks including MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK …

The T-cell receptor (TCR) signalling machinery is central in determining the response of a T
cell (establishing immunity or tolerance) following exposure to antigen. This process is made …

Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-restricted member of the
serine/threonine Ste20-related protein kinases, is a negative regulator of the T cell receptor …

Adaptors are molecular scaffolds that recruit effectors, which are critical for immune cell
activation. Recent work has underscored the requirement for adaptors in propagating …

The reversible phosphorylation of tyrosine residues is an important mechanism for
modulating biological processes such as cellular signaling, differentiation, and growth, and if …

Abstract Hematopoietic progenitor kinase 1 (HPK1), a 97-kDa serine/threonine Ste20-
related protein kinase, is a negative regulator of T cells, B cells, and dendritic cells-mediated …

Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the
activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 …

HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors
SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in …

We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus
kinase functions for negative immune cell regulation is poorly understood and critical to its …