Nuclear speckles: molecular organization, biological function and role in disease
L Galganski, MO Urbanek… - Nucleic acids …, 2017 - academic.oup.com
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
The case for junk DNA
AF Palazzo, TR Gregory - PLoS genetics, 2014 - journals.plos.org
With the advent of deep sequencing technologies and the ability to analyze whole genome
sequences and transcriptomes, there has been a growing interest in exploring putative …
sequences and transcriptomes, there has been a growing interest in exploring putative …
The role of TREX in gene expression and disease
CG Heath, N Viphakone, SA Wilson - Biochemical Journal, 2016 - portlandpress.com
TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex
The core components of the nuclear RNA export pathway are thought to be required for
export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in …
export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in …
Control of mammalian gene expression by selective mRNA export
VO Wickramasinghe, RA Laskey - Nature reviews Molecular cell biology, 2015 - nature.com
Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …
transcription in the nucleus to translation in the cytoplasm. Although important components …
Mechanisms of nuclear mRNA export: A structural perspective
Y Xie, Y Ren - Traffic, 2019 - Wiley Online Library
Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene
expression. As mRNA is synthesized, it is packaged with a myriad of RNA‐binding proteins …
expression. As mRNA is synthesized, it is packaged with a myriad of RNA‐binding proteins …
A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA
B Zhang, L Gunawardane, F Niazi… - … and cellular biology, 2014 - Taylor & Francis
The ubiquitous presence of long noncoding RNAs (lncRNAs) in eukaryotes points to the
importance of understanding how their sequences impact function. As many lncRNAs …
importance of understanding how their sequences impact function. As many lncRNAs …
Nuclear export of messenger RNA
J Katahira - Genes, 2015 - mdpi.com
Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step
of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of …
of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of …
[HTML][HTML] Splicing and beyond: the many faces of the Prp19 complex
S Chanarat, K Sträßer - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
Abstract The conserved Prp19 complex (Prp19C)—also known as NineTeen Complex
(NTC)—functions in several processes of paramount importance for cellular homeostasis …
(NTC)—functions in several processes of paramount importance for cellular homeostasis …
Sequence determinants for nuclear retention and cytoplasmic export of mRNAs and lncRNAs
AF Palazzo, ES Lee - Frontiers in genetics, 2018 - frontiersin.org
Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …