In contrast to genotoxic carcinogens, there are currently no internationally agreed upon
regulatory tools for identifying non-genotoxic carcinogens of human relevance. The rodent …

Chemical substances are subjected to assessment of genotoxic and carcinogenic effects
before being marketed to protect man and the environment from health risks. For …

Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats
by a mode of action (MOA) involving activation of the constitutive androstane receptor …

Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by
most regulatory authorities are lifetime carcinogenicity studies. However, these involve the …

Robust genomic approaches are now available to realize improvements in efficiencies and
translational relevance of cancer risk assessments for drugs and chemicals. Mechanistic …

A group of triazole compounds was selected to investigate the confidence that may be
associated with read-across of a complex data gap: repeated dose toxicity. The read-across …

Dioxane is an environmental contaminant that has been shown to cause cancer in rodents
after chronic high dose exposures. We reviewed and integrated information from recently …

The rodent cancer bioassays are conducted for agrochemical safety assessment yet they
often do not inform regulatory decision-making. As part of a collaborative effort, the …

Nongenotoxic chemicals can produce liver tumours in rats and mice by a mitogenic mode of
action involving activation of the constitutive androstane receptor (CAR). The aim of this …

In a 79 week bioassay the pesticide synergist piperonyl butoxide (PBO) was shown to
significantly increase the incidence of hepatocellular adenoma (but not hepatocellular …