Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

Background: Sarcopenia is characterized by the progressive loss of skeletal muscle mass,
strength, and function, significantly impacting overall health and quality of life in older adults …

An impairment in mitochondrial homeostasis plays a crucial role in the process of aging and
contributes to the incidence of age-related diseases, including sarcopenia, which is defined …

Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Sarcopenia is a disease characterized by the progressive loss of skeletal muscle mass and
function that occurs with aging. The progression of sarcopenia is correlated with the onset of …

Mitochondrial dysfunction is a hallmark of cancer cachexia (CC). Mitochondrial reactive
oxygen species (ROS) are elevated in muscle shortly after tumor onset. Targeting …

Sarcopenia lowers the quality‐of‐life for millions of people across the world, as accelerated
loss of skeletal muscle mass and function contributes to both age‐and disease‐related …

Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET
activation is a crucial etiological factor for thyroid cancer. RET is known to regulate …