Secondary metabolites with antioxidant activities for the putative treatment of amyotrophic lateral sclerosis (ALS):“Experimental evidences”

JM Silva, MSC Nobre, SL Albino… - Oxidative medicine …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that is characterized by
progressive loss of the upper and lower motor neurons at the spinal or bulbar level …

Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer

MS Bhuia, R Chowdhury, M Afroz… - Chemistry & …, 2025 - Wiley Online Library
Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the
Cupressaceae family, possesses important biological activities, including an anticancer …

[HTML][HTML] Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis

KM Varier, G Dan, W Liu, G Wu, C Xiao, H Lei… - Biomedicine & …, 2022 - Elsevier
Lymphoma is a cancer of the lymphoid cells that originated in matured B or T cells. The
bioactive natural compounds can efficiently treat this disease with lesser side effects. Thus …

[HTML][HTML] A natural acylphloroglucinol triggered antiproliferative possessions in HEL cells by impeding STAT3 signaling and attenuating angiogenesis in transgenic …

M Hu, KM Varier, Z Li, X Qin, Q Rao, J Song… - Biomedicine & …, 2021 - Elsevier
Leukemia is responsible for a reason of death, globally. Even though there are several
treatment regimens available in the clinics against this disease, a perfect chemotherapeutic …

BBD assisted in-situ nanoliposomes of esculin hydrate via intranasal delivery for the amelioration of Parkinson's disease

MS Ansari, A Ali, MA Rashid, Y Alhamhoom… - Journal of Drug Delivery …, 2024 - Elsevier
The objective of this research was to develop and optimise esculin Hydrate loaded
nanoliposomes (ESH-NLs). The nanoliposomes were prepared by solvent evaporation …

Garmultin-A Incites Apoptosis in CB3 Cells Through miR-17-5p by Attenuating Poly (ADP-Ribose) Polymerase-1

J Qiu, L Chen, J Yang, KM Varier… - Dose …, 2022 - journals.sagepub.com
Background Leukemia accounts for a large number of deaths, worldwide, every year.
Treating this ailment is always a challenging job. Recently, oncogenic miRNA leading to …

Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway

Q Rao, K Xie, KM Varier, L Huang, J Song… - Frontiers in …, 2022 - frontiersin.org
Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia
patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The …

Anticholinesterase activity of octa peptides related to human histatin 8: in-silico drug design and in-vitro

P Perumal, V Mani, S Chigurupati… - Asian Journal of …, 2017 - research.monash.edu
Objective: To evaluate the octapeptides related to human histatin 8 by in-silico and in-vitro
studies. Method: Schrodinger, LLC and Ellman's method. Results: The compound HH1 and …

[PDF][PDF] DOSE-DEPENDENT CHRONIC TOXICITY SCREENING OF HINOKITIOL IN ZEBRAFISHES: BEHAVIORAL AND HISTOLOGICAL APPROACH

KM VARIER, S THANGARAJAN - Asian J Pharm Clin Res, 2020 - academia.edu
Objectives: Parkinson's disease (PD) is categorized as a movement disorder symptomized
by weakening the motor skills of the patients. The root cause of the disease is the …

[引用][C] Effect of Imperatorin in Neuropathology of Parkinson's Disease: An In Silico Study

KM Varier, S Thangarajan, A Chinnasamy - Pharmaceutical and Clinical Research, 2017