Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Peptides promote the mitogenesis and migration of tumor cells, and cancer cells
overexpress peptide receptors. The involvement of the orexinergic system in cancer is …

Sanfilippo syndrome comprises a group of four genetic diseases due to the lack or
decreased activity of enzymes involved in heparan sulfate (HS) catabolism. HS …

Hypocretin-1 is a multifunctional neuropeptide that has been identified as a potential
antitumor agent for its role in inhibiting tumor growth, including in colon cancer …

Neuropeptides are small regulatory molecules found throughout the body, most notably in
the nervous, cardiovascular, and gastrointestinal systems. They serve as neurotransmitters …

Simple Summary This narrative review first describes from several points of view the
complex interrelationship between cancer and neurodegeneration, with special attention to …

Over 20 years ago, orexin neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-
2) produced from the same precursor in hypothalamus were identified. These two …

Prostate cancer (PCa) is the second most common cancer in humans. Peptides have
recently been used as targeted therapeutics in cancers, due to their extensive multi …

Background Colon cancer, ranked third in cancer related mortality, is the most common
malignant cancer of digestive tract. Though immune checkpoint inhibitors show promising …

Orexins (OxA and OxB) also termed hypocretins are hypothalamic neuropeptides involved in
central nervous system (CNS) to control the sleep/wake process which is mediated by two G …