Ca2+ is a universal signalling molecule involved in regulating cell cycle and fate,
metabolism and structural integrity, motility and volume. Like other cells, red blood cells …

Cell proliferation and apoptosis are paralleled by altered regulation of ion channels that play
an active part in the signaling of those fundamental cellular mechanisms. Cell proliferation …

The gene for hSK4, a novel human small conductance calcium-activated potassium
channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

Oxidative stress induces complex alterations of membrane proteins in red blood cells
(RBCs) eventually leading to haemolysis. To study changes of membrane ion permeability …

Cell shrinkage is a hallmark and contributes to signaling of apoptosis. Apoptotic cell
shrinkage requires ion transport across the cell membrane involving K+ channels, Cl− or …

The hydrophobic lipid bitayer of the red cell membrane is nearly impermeable for hydrophilic
solutes. Nevertheless, the transport of CO2 in the blood involves a rapid exchange of HCO3 …

The human intermediate-conductance, Ca2+-activated K+ channel (hIK) was identified by
searching the expressed sequence tag database. hIK was found to be identical to two …

Polymers of deoxyhemoglobin S deform sickle cell anemia red blood cells into sickle
shapes, leading to the formation of dense, dehydrated red blood cells with a markedly …