3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …
organized crypt–villus characteristics. This unique structure is necessary to maintain …
Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications
The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …
Synthetic microbial communities (SynComs) of the human gut are an assembly of …
Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
G Mahajan, E Doherty, T To, A Sutherland, J Grant… - Microbiome, 2022 - Springer
Background A dominance of non-iners Lactobacillus species in the vaginal microbiome is
optimal and strongly associated with gynecological and obstetric health, while the presence …
optimal and strongly associated with gynecological and obstetric health, while the presence …
Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip
Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2
receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the …
receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the …
Design and fabrication of organ-on-chips: promises and challenges
A Tajeddin, N Mustafaoglu - Micromachines, 2021 - mdpi.com
The advent of the miniaturization approach has influenced the research trends in almost all
disciplines. Bioengineering is one of the fields benefiting from the new possibilities of …
disciplines. Bioengineering is one of the fields benefiting from the new possibilities of …
Organ-on-chip models for infectious disease research
Research on microbial pathogens has traditionally relied on animal and cell culture models
to mimic infection processes in the host. Over recent years, developments in microfluidics …
to mimic infection processes in the host. Over recent years, developments in microfluidics …
Gut-on-a-chip models for dissecting the gut microbiology and physiology
A Valiei, J Aminian-Dehkordi, MRK Mofrad - APL bioengineering, 2023 - pubs.aip.org
Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips
In vitro models of human organs must accurately reconstitute oxygen concentrations and
gradients that are observed in vivo to mimic gene expression, metabolism, and host …
gradients that are observed in vivo to mimic gene expression, metabolism, and host …
Organoids and colorectal cancer
A Barbáchano, A Fernández-Barral… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is one of the most frequent and lethal types of cancer.
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …
Gut-on-a-Chip Models: Current and Future Perspectives for Host–Microbial Interactions Research
The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …