Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

Lectin galactoside-binding soluble 3 binding protein (LGALS3BP, also called Mac-2 binding
protein) is a heavily glycosylated secreted molecule that has been shown previously to be …

Aberrant glycosylation is a key feature of malignant transformation and reflects epigenetic
and genetic anomalies among the multitude of molecules involved in glycan biosynthesis …

Recent advances in the understanding of immune function and the interactions with tumour
cells have led to the development of various cancer immunotherapies and strategies for …

All cells in nature are covered with a dense and complex array of glycan chains. Specific
recognition and binding of glycans is a critical aspect of cellular interactions, both within and …

Advances in immunotherapy have revolutionized cancer treatment, yet many patients do not
show clinical responses. While most immunotherapies target T cells, myeloid cells are the …

Sialic acid (Sia)-binding immunoglobulin-like lectin 7 (Siglec-7) is an inhibitory receptor
primarily expressed on natural killer (NK) cells and monocytes. Siglec-7 is known to …

Breast cancer continues to have a high disease burden worldwide and presents an urgent
need for novel therapeutic strategies to improve outcomes. The influenza vaccine offers a …

Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal,
ST6Gal, ST6GalNAc, or ST8SIA with α2, 3-, α2, 6-, or α2, 8-linkages. Alteration of these …