Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate
intracellular signalling pathways that promote cancer cell survival and tumour growth …

Extensive knowledge has been gained on the transcription network controlled by ERα,
however, the mechanism underlying ESR1 (encoding ERα) expression is less understood …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …